聚乙二醇-醛基 mPEG-ALD (Methoxypolyethylene glycol aldehyde)

Description:

mPEG-aldehyde (propionaldehyde) reacts with amine and N-terminal of peptide and protein to form an imine containing a C=N double bond, which can be further reduced. PEG aldehyde or ketone derivatives can be used in reversible PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrozone linkage. PEG butyraldehyde may be offered through custom synthesis.

References:

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5. Mechanisms of activity loss for a multi-PEGylated protein by experiment and simulation, Materials Today Chemistry, 12, 2019, 121-131, Text.