功能化聚天冬氨酸基材料的生物医学应用《ACS Applied Polymer Materials》

功能化聚天冬氨酸基材料的生物医学应用

【摘要】

生物相容性和可生物降解的聚合物配方在各种生物医学应用中都是必需的。在各种聚合物中，近年来广泛使用基于聚天冬氨酸衍生物的制剂，因为其简单的合成方法、生物降解性、生物相容性以及在临床前研究中的成功验证。本文综述了聚天冬氨酸聚合物在纳米医学领域的新兴潜力。具体来说，本文综述了这些基于聚合物的制剂的发展及其在生物成像、药物传递和基因传递中的应用。首先，我们简要介绍了聚合物的合成和使用必需分子进行功能化以获得功能化聚天冬氨酸的方法。其次，广泛总结了这些功能化聚合物在不同生物医学领域的成功应用。特别是，总结了这些功能化聚合物作为无机纳米颗粒涂层材料、治疗剂输送载体和组织工程支架的成功开发。最后，强调了其在未来生物医学领域的应用潜力。

【关键词】聚琥珀酰亚胺，聚天冬氨酸，纳米粒子，聚合物胶束，纳米载体，诊断，治疗

Biomedical Applications of Functional Polyaspartamide-Based Materials

REVIEW

Pradip Das* and Nikhil R. Jana*

School of Materials Science, Indian Association for the Cultivation of Science, Kolkata-700032, India

ACS Appl. Polym. Mater. 2021, 3, 10, 4791–4811

Publication Date: September 3, 2021

https://doi.org/10.1021/acsapm.1c00785

ABSTRACT

Biocompatible and biodegradable polymeric formulations are required in diverse biomedical applications. Among various polymers, polyaspartamide-derivative-based formulations are extensively employed in recent years because of their simple synthesis methods, biodegradability, biocompatibility, and successful validations in preclinical research. The aim of this review is to provide an overview of the emerging potentials of polyaspartamide polymers in the field of nanomedicine. Specifically, this review describes the development of these polymer-based formulations and their applications in bioimaging, drug delivery, and gene delivery. At first, we briefly describe the methods of polymer synthesis and functionalization with essential molecules to derive functional polyaspartamide. Next, the successful utilization of these functional polymers in different biomedical fields is extensively summarized. In particular, the successful exploitation of these functional polymers as coating materials for inorganic nanoparticles, as delivery carriers for therapeutic agents, and as scaffolds in tissue engineering is summarized. Finally, the future biomedical application potential has been highlighted.

KEYWORDS: polysuccinimide, polyaspartamide, nanoparticle, polymer micelle, nanocarrier, diagnosis, therapy

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsapm.1c00785.

SI补充资料（PDF）中总结了各种生物医学应用中基于聚天冬氨酸的不同配方，图和示意图显示了从聚天冬氨酸衍生的不同类型的聚合物配方，用于癌症MRI的磁性聚离子复合囊泡的制备，用于图像引导癌症治疗的多功能纳米探针的制造，载抗癌药物的聚合物纳米颗粒的制备及其双刺激响应释放能力，以及与抗癌剂和刺激剂共聚的聚合物小体的制备和工作原理，用于将多刺激响应性药物输送到肿瘤微环境。

来源：《ACS Applied Polymer Materials》

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