聚乳酸-聚乙二醇-马来酰亚胺 PLA-PEG-MAL (Maleimide-PEG-Polylactic Acid) 生物降解两亲性二嵌段共聚物 端基修饰

Description:

Maleimide functionalized PEG-PLA is a useful reagent to prepare core-shell nanoparticles with a thiol-reactive maleimide for conjugation with peptide or proteins bearing free thiols. PEG-PLA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block polylactic acid or polylactide (PLA). The hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres.

References:

1) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.

2) Preparation, characterization and properties of polylactide (PLA) - poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. J Appl Polym Sci 1990;39: 1–9, Text.