聚乙烯亚胺-接枝-聚乙二醇 接枝共聚物 PEG化聚乙烯亚胺 PEG-g-PEI | PEG-g-LPEI (Linear PEI grafted with PEGs)

Description:

This product is a graft copolymer of linear PEI with multiple PEGs.

The PEG to PEI ratio is the average number of PEGs per PEI.   

For 22,000 MW PEI, PEG/PEI ratio of 15 is roughly 3% of PEI units grafted with PEGs.

Custom service is provided to produce PEG-PEI reagents with any MW of PEI and any MW of PEG at any graft ratio PEG-g(x)-PEI.

PEG-PEI, copolymers of cationic poly(ethylene imine) (PEI) and polyethylene glycol (PEG) are well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides and nucleic acids (DNA, siRNA).

By varying the MW of PEI and PEG, PEG-PEI drug conjugates, polyplexes or nanoparticles can be prepared with a dynamic range of size, surface charge, and stability, which all are important to the transfection efficiency.

PEG-PEI copolymers can be synthesized with customer specified MW.

References:

1. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy, RSC Adv., 2016, 6, 105871-105877, Text.

2. Critical Length of PEG Grafts on LPEI/DNA Nanoparticles for Efficient in Vivo Delivery, ACS Biomater. Sci. Eng. 2016, 2, 567−578, Text.