聚乙二醇-聚乙烯亚胺 二嵌段共聚物 PEG-b-LPEI (PEG-linear PEI) | PEG-PEI

Description:

This product is a block copolymer of linear PEI (LPEI) with linear PEG.

The terminal end of PEG is an inert, nonreactive group.

PEG-b-LPEI, copolymers of cationic poly(ethylene imine) (PEI) and polyethylene glycol (PEG) are well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides and nucleic acids (DNA, siRNA).

By varying the MW of PEI and PEG, PEG-PEI drug conjugates, polyplexes or nanoparticles can be prepared with a dynamic range of size, surface charge, and stability, which all are important to the transfection efficiency.

PEG-b-LPEI copolymers can be synthesized with customer specified MW.

Solubility:

Product is soluble in water, very sparingly soluble in dichloromethane.

References:

1. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy, RSC Adv., 2016, 6, 105871-105877, Text.