| PEG-PLGA (mPEG-PLGA) |
|
| DLG-10k30k91 | PEG-PLGA, PEG 10k & PLGA 30k, L:G 9:1 |
| DLG-10k90k31 | PEG-PLGA, PEG 10k & PLGA 90k, L:G 3:1 |
| DLG-10k90k91 | PEG-PLGA, PEG 10k & PLGA 90k, L:G 9:1 |
| DLG-2k10k11 | PEG-PLGA, PEG 2k & PLGA 10k, L:G 1:1 |
| DLG-5k10k31 | PEG-PLGA, PEG 5k & PLGA 10k, L:G 3:1 |
| DLG-5k15k11 | PEG-PLGA, PEG 5k & PLGA 15k, L:G 1:1 |
| DLG-5k15k31 | PEG-PLGA, PEG 5k & PLGA 15k, L:G 3:1 |
| DLG-5k15k91 | PEG-PLGA, PEG 5k & PLGA 15k, L:G 9:1 |
| DLG-5k45k91 | PEG-PLGA, PEG 5k & PLGA 45k, L:G 9:1 |
| DLG-5k55k31 | PEG-PLGA, PEG 5k & PLGA 55k, L:G 3:1 |
| DLG-5k75k31 | PEG-PLGA, PEG 5k & PLGA 75k, L:G 3:1 |
| DLG-5k80k31 | PEG-PLGA, PEG 5k & PLGA 80k, L:G 3:1 |
| MTO | PEG-PLGA, custom synthesis |
Description:
PEG-PLGA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block poly(lactide-co-glycolide) (PLGA). The PEG polymer is capped a methyl ether group, and the hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone). PEG-PLGA with other MWs is also offered.
References:
1. Inhibition of Karyopherin beta 1 suppresses prostate cancer growth, Nature Oncogene, 2019, doi: 10.1038/s41388-019-0745-2
2. Strategies to enhance the distribution of nanotherapeutics in the brain, Journal of Controlled Release, 2017, 10.1016/j.jconrel.2017.07.028, Text.
3. Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.
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