透明质酸-甲基丙烯酸酯 侧基双键 Hyaluronate Methacrylate (Hyaluronic Acid functionalized with MA)

Description:

Hyaluronic Acid is functionalized with methacrylate groups. Purity: >95% powder. Degree of substitution (DoS): 5 mol % substitution unless specifically noted in the catalog number. For example, HA-301-30% means that the DoS is 30% for this particular product. HA-Methacrylate with lower or higher methacrylate substitution ratio (e.g. 1% and 10%) may be offered through custom synthesis service. HA-Methacrylamide is offered by custom synthesis.

The methacrylate substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with methacrylate groups. You may calculate the number of methacrylate by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio to get the number of methacrylate in each HA polymer.

Literature:

1) Synthesis of polysaccharide chemical gels by gamma-ray irradiation, ACS Symposium Series, (1996), 620(13)(Irradiation of Polymers):180-7.

2) Hyaluronic acid based scaffolds for tissue engineering—A review, Carbohydrate Polymers 2013, 92(2):1262– 1279.