聚乙二醇-羧酸/羧基 Carboxylic acid PEG| Catalog No. | Product name & molecular weight |
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mPEG-AA (mPEG-Acetic Acid, mPEG-COOH) 甲氧基-聚乙二醇-乙酸 |  | | PSB-2200 | mPEG-AA, MW 350 | | PSB-223 | mPEG-AA, MW 550 | | PSB-2230 | mPEG-AA, MW 40k | | PSB-224 | mPEG-AA, MW 30k | | PSB-225 | mPEG-AA, MW 20k | | PSB-226 | mPEG-AA, MW 10k | | PSB-227 | mPEG-AA, MW 5k | | PSB-228 | mPEG-AA, MW 2k | | PSB-229 | mPEG-AA, MW 1k | mPEG-GA (Monofunctional PEG Glutaric Acid) 甲氧基-聚乙二醇-戊二酸 |  | | PSA-287 | mPEG-GA, MW 5k | | PSA-288 | mPEG-GA, MW 2k | | PSB-283 | mPEG-GA, MW 550 | | PSB-284 | mPEG-GA, MW 30k | | PSB-2840 | mPEG-GA, MW 40k | | PSB-285 | mPEG-GA, MW 20k | | PSB-286 | mPEG-GA, MW 10k | | PSB-289 | mPEG-GA, MW 1k | mPEG-SA (Monofunctional PEG Succinic Acid) 甲氧基-聚乙二醇-丁二酸(琥珀酸) |  | | PSB-2090 | mPEG-SA, MW 40k | | PSB-2091 | mPEG-SA, MW 1k | | PSB-2092 | mPEG-SA, MW 2k | | PSB-2093 | mPEG-SA, MW 5k | | PSB-2094 | mPEG-SA, MW 10k | | PSB-2095 | mPEG-SA, MW 20k | | PSB-2096 | mPEG-SA, MW 30k | | PSB-2097 | mPEG-SA, MW 550 | mPEG-GAA (Monofunctional PEG Glutaramide Acid) 甲氧基-聚乙二醇-戊二酰胺酸 |  | | PSB-2071 | mPEG-GAA, MW 1k | | PSB-2072 | mPEG-GAA, MW 2k | | PSB-2073 | mPEG-GAA, MW 5k | | PSB-2074 | mPEG-GAA, MW 10k | | PSB-2075 | mPEG-GAA, MW 20k | | PSB-2076 | mPEG-GAA, MW 30k | | PSB-2077 | mPEG-GAA, MW 550 | | PSB-2078 | mPEG-GAA, MW 40k | mPEG-SAA (Monofunctional PEG Succinamide Acid) 甲氧基-聚乙二醇-琥珀酰胺酸 |  | | PSB-2131 | mPEG-SAA, MW 1k | | PSB-2132 | mPEG-SAA, MW 2k | | PSB-2133 | mPEG-SAA, MW 5k | | PSB-2134 | mPEG-SAA, MW 10k | | PSB-2135 | mPEG-SAA, MW 20k | | PSB-2136 | mPEG-SAA, MW 30k | | PSB-2137 | mPEG-SAA, MW 550 | | PSB-2138 | mPEG-SAA, MW 40k | AA-PEG-AA (Acid-PEG-Acid, AA - acetic acid or carboxyl methyl) 乙酸-聚乙二醇-乙酸 |  | | PSB-360 | AA-PEG-AA, MW 600 | | PSB-361 | AA-PEG-AA, MW 1k | | PSB-362 | AA-PEG-AA, MW 2k | | PSB-363 | AA-PEG-AA, MW 3.4k | | PSB-364 | AA-PEG-AA, MW 5k | | PSB-365 | AA-PEG-AA, MW 10k | | PSB-366 | AA-PEG-AA, MW 20k | GA-PEG-GA (Acid - PEG - Acid, GA: Glutaric acid) 戊二酸-聚乙二醇-戊二酸 |  | | PSB-367 | GA-PEG-GA, MW 600 | | PSB-368 | GA-PEG-GA, MW 1k | | PSB-369 | GA-PEG-GA, MW 2k | | PSB-370 | GA-PEG-GA, MW 3.4k | | PSB-371 | GA-PEG-GA, MW 5k | | PSB-372 | GA-PEG-GA, MW 10k | | PSB-373 | GA-PEG-GA, MW 20k | | PSB-374 | GA-PEG-GA, MW 35k | SA-PEG-SA (Bifunctional PEG carboxylic acid - Succinic Acid) 丁二酸-聚乙二醇-丁二酸(琥珀酸) |  | | PSB-3340 | SA-PEG-SA, MW 600 | | PSB-3341 | SA-PEG-SA, MW 1k | | PSB-3342 | SA-PEG-SA, MW 2k | | PSB-3343 | SA-PEG-SA, MW 3.4k | | PSB-3344 | SA-PEG-SA, MW 5k | | PSB-3345 | SA-PEG-SA, MW 10k | | PSB-3346 | SA-PEG-SA, MW 20k | GAA-PEG-GAA (Bifunctional PEG carboxylic acid, Glutaramide Acid) 戊二酰胺酸-聚乙二醇-戊二酰胺酸 |  | | PSB-3350 | GAA-PEG-GAA, MW 600 | | PSB-3351 | GAA-PEG-GAA, MW 1k | | PSB-3352 | GAA-PEG-GAA, MW 2k | | PSB-3353 | GAA-PEG-GAA, MW 3.4k | | PSB-3354 | GAA-PEG-GAA, MW 5k | | PSB-3355 | GAA-PEG-GAA, MW 10k | | PSB-3356 | GAA-PEG-GAA, MW 20k | SAA-PEG-SAA (Bifunctional PEG carboxylic acid, Succinamide Acid) 琥珀酰胺酸-聚乙二醇-琥珀酰胺酸 |  | | PSB-3370 | SAA-PEG-SAA, MW 600 | | PSB-3371 | SAA-PEG-SAA, MW 1k | | PSB-3372 | SAA-PEG-SAA, MW 2k | | PSB-3373 | SAA-PEG-SAA, MW 3.4k | | PSB-3374 | SAA-PEG-SAA, MW 5k | | PSB-3375 | SAA-PEG-SAA, MW 10k | | PSB-3376 | SAA-PEG-SAA, MW 20k | HO-PEG-COOH (Hydroxyl PEG Carboxylic acid) 羟基-聚乙二醇-乙酸 |  | | PHB-910 | HO-PEG-COOH, MW 2k | | PHB-911 | HO-PEG-COOH, MW 3.4k | | PHB-912 | HO-PEG-COOH, MW 5k | | PHB-913 | HO-PEG-COOH, MW 10k | | PHB-914 | HO-PEG-COOH, MW 1k | NH2-PEG-COOH (Amine PEG Carboxylic acid) 胺-聚乙二醇-乙酸 |  | | PHB-930 | NH2-PEG-COOH, MW 2k | | PHB-931 | NH2-PEG-COOH, MW 3.4k | | PHB-932 | NH2-PEG-COOH, MW 5k | | PHB-933 | NH2-PEG-COOH, MW 10k | | PHB-934 | NH2-PEG-COOH, MW 1k | Boc-NH-PEG-COOH (Boc protected Amine PEG Carboxylic Acid) Boc保护胺-聚乙二醇-乙酸 |  | | PHB-1950 | Boc-NH-PEG-COOH, MW 1k | | PHB-1951 | Boc-NH-PEG-COOH, MW 2k | | PHB-1952 | Boc-NH-PEG-COOH, MW 3.4k | | PHB-1953 | Boc-NH-PEG-COOH, MW 5k | | PHB-1954 | Boc-NH-PEG-COOH, MW 10k | Fmoc-NH-PEG-COOH (Fmoc protected Amine PEG Carboxylic Acid) Fmoc保护胺-聚乙二醇-乙酸 |  | | PHB-1955 | Fmoc-NH-PEG-COOH, MW 1k | | PHB-1956 | Fmoc-NH-PEG-COOH, MW 2k | | PHB-1957 | Fmoc-NH-PEG-COOH, MW 3.4k | | PHB-1958 | Fmoc-NH-PEG-COOH, MW 5k | | PHB-1959 | Fmoc-NH-PEG-COOH, MW 10k | MAL-PEG-COOH (Maleimide PEG Carboxylic acid) 马来酰亚胺-聚乙二醇-乙酸 |  | | PHB-955 | MAL-PEG-COOH, MW 1k | | PHB-956 | MAL-PEG-COOH, MW 2k | | PHB-957 | MAL-PEG-COOH, MW 3.4k | | PHB-958 | MAL-PEG-COOH, MW 5k | | PHB-959 | MAL-PEG-COOH, MW 10k | OPSS-PEG-COOH (Orthopyridyl disulfide (PDP) PEG Carboxylic acid) 吡啶基二硫醚-聚乙二醇-乙酸 |  | | PHB-1990 | OPSS-PEG-COOH, MW 1k | | PHB-1991 | OPSS-PEG-COOH, MW 2k | | PHB-1992 | OPSS-PEG-COOH, MW 3.4k | | PHB-1993 | OPSS-PEG-COOH, MW 5k | | PHB-1994 | OPSS-PEG-COOH, MW 10k | AC-PEG-COOH (Acrylate PEG Carboxylic acid) 丙烯酸酯-聚乙二醇-乙酸 末端双键 |  | | PHB-1980 | AC-PEG-COOH, MW 1k | | PHB-1981 | AC-PEG-COOH, MW 2k | | PHB-1982 | AC-PEG-COOH, MW 3.4k | | PHB-1983 | AC-PEG-COOH, MW 5k | | PHB-1984 | AC-PEG-COOH, MW 10k | Biotin-PEG-COOH (Biotin PEG Carboxylic acid) 生物素-聚乙二醇-乙酸 |  | | PJK-1935 | Biotin-PEG-COOH, MW 1k | | PJK-1936 | Biotin-PEG-COOH, MW 2k | | PJK-1937 | Biotin-PEG-COOH, MW 3.4k | | PJK-1938 | Biotin-PEG-COOH, MW 5k | | PJK-1939 | Biotin-PEG-COOH, MW 10k | HS-PEG-COOH (Thiol PEG Carboxylic acid) 硫醇-聚乙二醇-乙酸 |  | | PBL-8073 | HS-PEG-COOH, MW 1k | | PBL-8074 | HS-PEG-COOH, MW 2k | | PBL-8075 | HS-PEG-COOH, MW 3.4k | | PBL-8076 | HS-PEG-COOH, MW 5k | | PBL-8077 | HS-PEG-COOH, MW 10k | DSPE-PEG-COOH (Carboxylic acid functionalized PEG Lipid) DSPE磷脂-聚乙二醇-乙酸 | | | PLS-9911 | DSPE-PEG-COOH, MW 1k | | PLS-9912 | DSPE-PEG-COOH, MW 2k | | PLS-9913 | DSPE-PEG-COOH, MW 3.4k | | PLS-9914 | DSPE-PEG-COOH, MW 5k | | FITC-PEG-COOH (Fluorescein PEG Carboxyl Acid) | | FITC荧光素-聚乙二醇-羧酸 | | PHB-3922 | FITC-PEG-COOH, MW 2k | | PHB-3923 | FITC-PEG-COOH, MW 3.4k | | PHB-3925 | FITC-PEG-COOH, MW 5k | 4-Arm PEG-Acid (Multi-arm - four arm - PEG Carboxylic Acid COOH) 4臂星形-聚乙二醇-乙酸 | | | PSB-480 | 4-Arm PEG-Acid, MW 2k | | PSB-481 | 4-Arm PEG-Acid, MW 10k | | PSB-482 | 4-Arm PEG-Acid, MW 20k | | PSB-483 | 4-Arm PEG-Acid, MW 5k | 4-Arm PEG-GA (Multi-arm - four arm - PEG Glutaric Acid) 4臂星形-聚乙二醇-戊二酸 | | | PSB-466 | 4-Arm PEG-GA, MW 2k | | PSB-467 | 4-Arm PEG-GA, MW 10k | | PSB-468 | 4-Arm PEG-GA, MW 20k | | PSB-469 | 4-Arm PEG-GA, MW 5k | 4-Arm PEG-SA (Multi-arm - four arm - PEG Succinic Acid) 4臂星形-聚乙二醇-丁二酸(琥珀酸) | | | PSB-4040 | 4-Arm PEG-SA, MW 2k | | PSB-4041 | 4-Arm PEG-SA, MW 5k | | PSB-4042 | 4-Arm PEG-SA, MW 10k | | PSB-4045 | 4-Arm PEG-SA, MW 20k | 4-Arm PEG-GAA (Multi-arm - four arm - PEG Glutaramide Acid) 4臂星形-聚乙二醇-戊二酰胺酸 | | | PSB-4050 | 4-Arm PEG-GAA, MW 2k | | PSB-4051 | 4-Arm PEG-GAA, MW 5k | | PSB-4052 | 4-Arm PEG-GAA, MW 10k | | PSB-4055 | 4-Arm PEG-GAA, MW 20k | 4-Arm PEG-SAA (Multi-arm - four arm - PEG Succinamide Acid) 4臂星形-聚乙二醇-琥珀酰胺酸 | | | PSB-4060 | 4-Arm PEG-SAA, MW 2k | | PSB-4061 | 4-Arm PEG-SAA, MW 5k | | PSB-4062 | 4-Arm PEG-SAA, MW 10k | | PSB-4065 | 4-Arm PEG-SAA, MW 20k | 8-Arm PEG-Acid (Multi-arm - eight arm - PEG Carboxylic Acid COOH) 8臂星形-聚乙二醇-乙酸 | | | PSB-831 | 8-Arm PEG-Acid, MW 10k | | PSB-832 | 8-Arm PEG-Acid, MW 20k | | PSB-834 | 8-Arm PEG-Acid, MW 40k | 8-Arm PEG-GA (Multi-arm - eight arm - PEG Glutaric Acid) 8臂星形-聚乙二醇-戊二酸 | | | PSB-836 | 8-Arm PEG-GA, MW 10k | | PSB-837 | 8-Arm PEG-GA, MW 20k | | PSB-839 | 8-Arm PEG-GA, MW 40k | 8-Arm PEG-SA (Multi-arm - eight arm - PEG Succinic Acid) 8臂星形-聚乙二醇-丁二酸(琥珀酸) | | | PSB-8011 | 8-Arm PEG-SA, MW 10k | | PSB-8012 | 8-Arm PEG-SA, MW 20k | | PSB-8014 | 8-Arm PEG-SA, MW 40k | 8-Arm PEG-GAA (Multi-arm - eight arm - PEG Carboxylic Acid COOH) 8臂星形-聚乙二醇-戊二酰胺酸 | | | PSB-8021 | 8-Arm PEG-GAA, MW 10k | | PSB-8022 | 8-Arm PEG-GAA, MW 20k | | PSB-8023 | 8-Arm PEG-GAA, MW 40k | 8-Arm PEG-SAA (Multi-arm - eight arm - PEG Carboxylic Acid COOH) 8臂星形-聚乙二醇-琥珀酰胺酸 | | | PSB-8031 | 8-Arm PEG-SAA, MW 10k | | PSB-8032 | 8-Arm PEG-SAA, MW 20k | | PSB-8034 | 8-Arm PEG-SAA, MW 40k | C18-PEG4-COOH (Tetraethylene glycol octadecyl ether carboxyl acid) 十八烷基醚-低聚四乙二醇-羧酸 | | | PMD-7002 | C18-PEG4-COOH, PEG MW 176 Da | C18-PEG6-COOH (Hexaethylene glycol octadecyl ether carboxyl acid) 十八烷基醚-低聚六乙二醇-羧酸 | | | PMD-7022 | C18-PEG6-COOH, PEG MW 264 Da | C18-PEG12-COOH (Dodecaethylene glycol octadecyl carboxylic acid) 十八烷基醚-低聚十二乙二醇-羧酸 | | | PMD-7042 | C18-PEG12-COOH, PEG MW 528 Da | | Pyrene-PEG-COOH | | 芘-聚乙二醇-羧酸 | | PBL-9021 | Pyrene-PEG-COOH, MW 1k | | PBL-9022 | Pyrene-PEG-COOH, MW 2k | | PBL-9023 | Pyrene-PEG-COOH, MW 3.4k | | PBL-9024 | Pyrene-PEG-COOH, MW 5k | | PBL-9025 | Pyrene-PEG-COOH, MW 10k | Dendro Acid-PEG-Dendro Acid (PEG Hyperbranched Dendrimer Acid) 超支化树枝状酸-聚乙二醇-超支化树枝状酸 | | | HBP-121 | Dendro Acid-PEG-Dendro Acid, PEG 10k, G3 16 Acid | | HBP-122 | Dendro Acid-PEG-Dendro Acid, PEG 10k, G4 32 Acid | | HBP-123 | Dendro Acid-PEG-Dendro Acid, PEG 10k, G5 64 Acid | | HBP-124 | Dendro Acid-PEG-Dendro Acid, PEG 10k, G6 128 Acid | mPEG-Dendro Acid (PEG Dendrimer Acid) 甲氧基-聚乙二醇-超支化树枝状酸 | | | PDP-301 | mPEG-Dendro Acid, PEG 2k, G2 4 Acid | | PDP-302 | mPEG-Dendro Acid, PEG 2k, G3 8 Acid | | PDP-303 | mPEG-Dendro Acid, PEG 2k, G4 16 Acid | | PDP-311 | mPEG-Dendro Acid, PEG 5k, G2 4 Acid | | PDP-312 | mPEG-Dendro Acid, PEG 5k, G3 8 Acid | | PDP-313 | mPEG-Dendro Acid, PEG 5k, G4 16 Acid |
Q: What are the differences among your PEG NHS ester & PEG Acid products? A: We offer a variety of PEG Acid and PEG NHS ester. These NHS esters react with primary and secondary amine to form a stable amide linkage. This reaction may be carried out in an organic solution with an organic base or may be carried out in an aqueous solution at or around neutral pH or slightly acidic or basic. To PEGylate proteins or nanoparticles, it often requires a large excess of PEG NHS esters due to the competitive hydrolysis reaction in an aqueous solution. Stability of NHS esters is compared by their hydrolysis half-life (T1/2). To mitigate the competitive hydrolysis reaction, organic solvents such as amine-free, anhydrous DMF and DMSO may be used in combination with an aqueous buffer solution. PEG NHS esters | Structural characteristics | Amine reactivity | Stability |
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| Type A: SCM | Methylene (CH2) linkage between PEG and NHS ester | Highly reactive | Hydrolysis half-life: less than five minutes. It often requires the use of a large excess of PEG reagents. | | Type B: SG | C4 aliphatic ester linkage between PEG and NHS ester | Very reactive | Hydrolysis half-life: around 20 minutes. | | Type C: SS | C3 aliphatic ester linkage between PEG and NHS ester | Very reactive | Hydrolysis half-life: around 10 minutes. | | Type D: GAS | C4 aliphatic amide linkage between PEG and NHS ester | Very reactive | Hydrolysis half-life: around 20 minutes. | | Type E: SAS | C3 aliphatic amide linkage between PEG and NHS ester | Very reactive | Hydrolysis half-life: around 10 minutes. |
SCM: Succinimidyl Carboxyl Methyl ester; SG: Succinimidyl Glutarate ester; SS: Succinimidyl Succinate ester; GAS: GlutarAmide Succinimidyl ester; SAS: SuccinAmide Succinimidyl ester. Note: hydrolysis half-life depends on pH, temperature and other factors of the testing conditions. | PEG acids | Structural characteristics |
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| Type A: AA | Methylene (CH2) linkage between PEG and acid (COOH) | | Type B: GA | C4 aliphatic ester linkage between PEG and acid (COOH) | | Type C: SA | C3 aliphatic ester linkage between PEG and acid (COOH) | | Type D: GAA | C4 aliphatic amide linkage between PEG and acid (COOH) | | Type E: SAA | C3 aliphatic amide linkage between PEG and acid (COOH) |
AA: Acetic Acid, also called CM - Carboxyl Methyl; GA: Glutaric Acid; SA: Succinic Acid; GAA: GlutarAmide Acid; SAS: SuccinAmide Acid.
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