| 8-Arm PEG-PCL (8-Arm PEG-PCL) |
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| 8C-20k10k | 8-Arm PEG-PCL, PEG 20k & PCL 10k |
| 8C-20k80k | 8-Arm PEG-PCL, PEG 20k & PCL 80k |
| 8C-40k10k | 8-Arm PEG-PCL, PEG 40k & PCL 10k |
| 8C-40k80k | 8-Arm PEG-PCL, PEG 40k & PCL 80k |
Description:
8-Arm PEG-PCL is a 8-arm PEG with one PCL block on each of the 8 PEG arms.
The MW of PEG or PCL refers to the total MW of all 8 arms.
PEG-PCL is an AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block polycaprolactone (PCL).
Biocompatible PEGylated copolymers with biodegradable polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres.
The hydrolytic degradability of the polyester block depends on the molecular weight and the spacer between ester groups (lactide, glycotide or caprolactone).
PEG-PCL with other MWs is also offered.
References:
1) Site-Specific Addressing of Particles and Coatings via Enzyme-Mediated Destabilization, Catalysts 2019, 9, 354; Text.
2) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.
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